transgenic animals in immunology
« Characterization of brain dystrophins absence and impact in dystrophin-deficient Dmdmdx rat model ». PloS One, 9(10), e110371. Remy, S., Chenouard, V., Tesson, L., Usal, C., Ménoret, S., Brusselle, L., … Anegon, I. COVID-19 is an emerging, rapidly evolving situation. Transgenic animals are certainly a good turn of events since transgenic technology holds great potential in many fields, ... microbiology and immunology: A Revie w. Ann. Tesson, L., Usal, C., Ménoret, S., Leung, E., Niles, B. J., Remy, S., … Cost, G. J. Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models. Tau in serum reaches higher levels than control groups when immunizing with DA31 (***p<0.001) or DA9 (****p<0.0001). Ménoret, S., Tesson, L., Remy, S., Usal, C., Ouisse, L.-H., Brusselle, L., … Anegon, I. Reproducible survival of porcine xenografts for more than 6 months in non-human primate recipients is considered to be a necessary precondition to starting clinical trials with human patients ( Petersen et al., 2009a ). Ceruloplasmin Deficiency Does Not Induce Macrophagic Iron Overload: Lessons from a New Rat Model of Hereditary Aceruloplasminemia. (2014). Frontiers in Immunology 10 (septembre): 2131. https://doi.org/10.3389/fimmu.2019.02131, Caudal, Dorian, Virginie François, Aude Lafoux, Mireille Ledevin, Ignacio Anegon, Caroline Le Guiner, Thibaut Larcher, et Corinne Huchet. 1800 Rev. TRIP platform has been created in 1996 and has ever since developed Knock-Out (KO) or Knock-In (KI) rat research models for all (academic or private labs, French or international companies…), To discuss your own project or if you are interested in our available research models, please contact Ignacio Anegon, Remy, S. et al. Braudeau, C., Bouchet, D., Toquet, C., Tesson, L., Ménoret, S., Iyer, S., Laboisse, C., Willis, D., Jarry, A., Buelow, R., Anegon, I., & Chauveau, C. (2003). 2019. Transgenic animals are those that, as a consequence of experimental DNA transfer application, have exogenous DNA integrated in their germ line. R01 AG022102/AG/NIA NIH HHS/United States, R37 AG022102/AG/NIA NIH HHS/United States. Not logged in Aubert, D., Ménoret, S., Chiari, E., Pichard, V., Durand, S., Tesson, L., Moullier, P., Anegon, I., & Ferry, N. (2002). (2019). lacZ transgenic rats tolerant for beta-galactosidase: Recipients for gene transfer studies using lacZ as a reporter gene. Gene targeting in rats using transcription activator-like effector nucleases. Serum tau in dose-response experiments using DA9 or MC1 antibody, Figure 6. Pronuclear injection for the production of transgenic rats. Plasma tau is expressed as ng/ml. Detecting tau in serum of transgenic animal models after tau immunotherapy treatment. Lopez Robles, M. D., Pallier, A., Huchet, V., Le Texier, L., Remy, S., Braudeau, C., … Chiffoleau, E. (2017). 2018 Aug 22;6(1):82. doi: 10.1186/s40478-018-0585-2. Kenawi, Moussa, Emmanuel Rouger, Marie-Laure Island, Patricia Leroyer, François Robin, Séverine Rémy, Laurent Tesson, et al. doi: 10.1371/journal.pone.0135774. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminative human monoclonal antibodies. Ménoret, S., Tesson, L., Remy, S., Usal, C., Iscache, A.-L., Thynard, R., … Anegon, I. A., Baldassarre, H., & Crispo, M. (2016). Transgenic animals and genetic engineering techniques. Get the latest research from NIH: https://www.nih.gov/coronavirus. (2011). Human plasma reactivity in tau…, Figure 7. Epub 2014 Aug 1. Charreau, B., Ménoret, S., Tesson, L., Soulillou, J.-P., & Anegon, I. Geurts, A. M., Cost, G. J., Rémy, S., Cui, X., Tesson, L., Usal, C., … Buelow, R. (2010). Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Levels of tau in human serum are less than the sensitivity of current assays, although artifactual signals are common. “Transgenesis, recent technical developments and applications” Nantes, 8th June 2009. of Cell, Developmental, and Integrative Biology Osborn, M. J., Ma, B., Avis, S., Binnie, A., Dilley, J., Yang, X., … Brüggemann, M. (2013). Menchaca, A., Anegon, I., Whitelaw, C. B. 2020 Aug 6;8(1):126. doi: 10.1186/s40478-020-01003-7. Remy, Séverine, Nguyen, T. H., Ménoret, S., Tesson, L., Usal, C., & Anegon, I. (2012). Charreau, B., Ménoret, S., Tesson, L., Azimzadeh, A., Audet, M., Wolf, P., Marquet, R., Verbakel, C., Ijzermans, J., Cowan, P., Pearse, M., d’Apice, A., Soulillou, J. P., & Anegon, I. Part of Springer Nature. Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. https://doi.org/10.1007/s11248-009-9352-2, Larcher, T., Lafoux, A., Tesson, L., Remy, S., Thepenier, V., François, V., … Huchet, C. (2014). George A. Kollias, in Encyclopedia of Immunology (Second Edition), 1998. Ouisse, Laure-Hélène, Séverine Remy, Aude Lafoux, Thibaut Larcher, Laurent Tesson, Vanessa Chenouard, Carole Guillonneau, et al. Lambert, Mélanie, Véronique Capuano, Angèle Boet, Laurent Tesson, Thomas Bertero, Morad K. Nakhleh, Séverine Remy, et al. Ranchoux, B., Antigny, F., Rucker-Martin, C., Hautefort, A., Péchoux, C., Bogaard, H. J., … Perros, F. (2015). Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cells-derived hepatic stem cells. 株式会社トランスジェニックの学会・論文発表ページです。 私達は生物個体からゲノムにいたる生命資源の開発を通じて基盤研究および医学・医療の場に遺伝情報を提供しその未来に資するとともに世界の人々の健康と豊かな暮らしの実現に貢献して参ります。 Transgenic technologies form today the core of ‘interventional genetics’, a key methodology for analyzing and interfering with gene function in whole animals. In immunotoxicology, although the potential usefulness of transgenic mice is widely recognized, practical application has been limited. Transgenic Animals Derived by DNA Microinjection. Am J Respir Cell Mol Biol 27:396–405, Moser R, Quesniaux V, Ryffel B (2001) Use of transgenic animals to investigate drug hypersensitivity. Verbakel, C. A., Anegon, I., Ménoret, S., Marquet, R. L., & Ijzermans, J. N. (2001). Human plasma reactivity in tau ELISA, NaOAc/heat treatment removes all the interfering molecules…, NLM (2011). (1997). Nantes, France, 2-3 July, 2015. Not affiliated Copyright © 2016 Elsevier Inc. All rights reserved. (2005). Tesson, L., Charreau, B., Ménoret, S., Gilbert, E., Soulillou, J. P., & Anegon, I. Ouisse, L.-H., Remy, S., Lafoux, A., Larcher, T., Tesson, L., Chenouard, V., … Anegon, I. Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases. Ménoret, S., Iscache, A.-L., Tesson, L., Rémy, S., Usal, C., Osborn, M. J., … Anegon, I. Charreau, B., Tesson, L., Menoret, S., Buscail, J., Soulillou, J. P., & Anegon, I. Transgenic Animal Transgenic animals expressing miR-27b in Pax3-positive cells display a shift from Pax3/7-positive progenitor cells to cells that are myogenin-positive and have entered myogenic differentiation. rthrash@asfa.k12.al.us . Birmingham, AL 35203 rthrash@ Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes. In Vivo Analysis of Human Immune Responses in Immunodeficient Rats. d'Abramo C, Acker CM, Jimenez H, Davies P. PLoS One. Knockout rats generated by embryo microinjection of TALENs. Pharm Res 14:1472–1478, Bugelski PJ, Herzyk DJ, Rehm S et al (2000) Preclinical development of keliximab, a primatized anti-CD4 monoclonal antibody, in human CD4 transgenic mice: characterization of the model and safety studies. Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease. Epub 2015 Apr 3. (2015). No functional benefit for hDAF-transgenic rat livers despite protection from tissue damage following perfusion with human serum. (2010). In the attempt to elucidate if the "peripheral sink hypothesis" could be a potential mechanism of action for tau removal in passive immunotherapy experiments, we have examined tau levels in serum of chronically injected JNPL3 and Tg4510 transgenic animals. | 30 Bd Jean Monnet Yadikar H, Torres I, Aiello G, Kurup M, Yang Z, Lin F, Kobeissy F, Yost R, Wang KK. Tau immunotherapy for Alzheimer's disease. Ittner A, Bertz J, Suh LS, Stevens CH, Götz J, Ittner LM. (2020). Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases. Protection against hyperacute xenograft rejection of transgenic rat hearts expressing human decay accelerating factor (DAF) transplanted into primates. Gordon JW. (2002). Transgenic Research, 19(5), 745‑763. 44093 Nantes Cedex 01 The Use of Transgenic Animals in the Study of Colitis: The Link between Molecular Biology and Immunology . Hum Exp Toxicol 19:230–243, Francini G, Scardino A, Kosmatopoulos K et al (2002) High-affinity HLA-A(*)02.01 peptides from parathyroid hormone-related protein generate in vitro and in vivo antitumor CTL response without autoimmune side effects. Nantes, France, June 7th 2013. Generation of Transgenic Rats Using Microinjection of Plasmid DNA or Lentiviral Vectors. There are two principal methods by which transgenic mice are created: microinjection of genetic material into the pronucleus... Over 10 million scientific documents at your fingertips. https://doi.org/10.1371/journal.pone.0230083, CHU Nantes - Hôtel Dieu (2010). In S. Pease & T. L. Saunders (Éd.). The present data show that pan-tau and conformational antibodies do increase tau in mouse sera. Martin, J. C., Bériou, G., Heslan, M., Bossard, C., Jarry, A., Abidi, A., … Josien, R. (2016). 2016 Mar;11(1):9-25. doi: 10.1007/s11481-015-9637-6. PMID: 3084963 [PubMed - indexed for MEDLINE] MeSH Terms Animals Cloning, Molecular Collodion Electrophoresis, Polyacrylamide Gel Genes, MHC Class II Genetic Engineering Geurts, A. M., Cost, G. J., Freyvert, Y., Zeitler, B., Miller, J. C., Choi, V. M., … Buelow, R. (2009).
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